Understanding the capabilities and potential within each component may explain both the process and usefulness of obtaining optimal specimens and elucidate exactly how tissue is evaluated. A: Probably, yes. All rights reserved. Bone marrow can be purchased from farmers markets, butcher shops, and health food stores. Immediately after the core biopsy is obtained, the procured tissue is "touched" several times onto glass slides. Once cool, cut into thin slices and store covered in the refrigerator while you prepare the vinaigrette. Quick tip: If the bone marrow is involved by metastatic carcinoma or clusters of cohesive plasma cells, these abnormal cells may not be amenable to aspiration and may cause a dry tap; however, a bone core biopsy will identify them. It has a rich, slightly sweet flavor with a smooth texture and is often served alongside toast or used as a base for soup. WebScallop, bone marrow, vinaigrette, celeriac, celery- another okay dish. Sprinkle with sea salt. Using a paring knife, remove raw marrow from bones, and slice thinly; reserve. Use on steaks, lamb and pork dishes, or a base for stews, soups and gravies. Bordelaise sauce works particularly well with fillet mignon. For example, the steak tartare includes a smoked bone marrow vinaigrette and housemade salt and vinegar There arent any notes yet. Enjoy! Some components are more useful for particular studies. Salt the water generously and stir until the salt dissolves. Low and high power of clot particle. Recipe from Amalga Distillery at https://ediblealaska.ediblecommunities.com/recipes/brussels-and-bone-panna-cotta. I'm interested to see that you don't use butter to emulsify the sauce at the end of cooking. She always prepared recipes that were new to me, but that always delighted my palate. Directly targeting bone marrow is leukemia, which is a blood and bone marrow cancer. The clot sections, core biopsy, marrow aspirate, and touch preps all contribute to the overall assessment of patients collected marrow. Bone marrow is in the center of most bones and in the end of spongy bones in your body. Put roasted bones, parsley salad, salt and toast on a large plate. For braising pot roasts and short ribs, add contents of pouch to gallon of water and simmer in crock pot until meat is fork tender. What would the difference in the end result be with the two variations (ie with and without butter)? This article reviews the nutrition and benefits of bone marrow and tells you how to add it to your diet. thinly sliced, Kosher salt and freshly ground black pepper, to taste, Chicory or other peppery lettuce, to serve, Celery leaves and fleur de sel, to garnish. saucepan over high heat, and add bones; cook until bones are bright white, about 45 minutes. Arthritis Research & Therapy: Is there any evidence for the use of glucosamine in the management of human osteoarthritis?, Cell Metabolism: Bone Marrow Adipose Tissue Is an Endocrine Organ that Contributes to Increased Circulating Adiponectin during Caloric Restriction., GreatBritishChefs.com: How to cook bone marrow., Harvard Health Publishing: Foods that fight inflammation., International Journal of Circumpolar Health: Level of selected nutrients in meat, liver, tallow and bone marrow from semi-domesticated reindeer., Journal of Cosmetic Dermatology: Collagen: A review on its sources and potential cosmetic applications., The Journal of the Pakistan Medical Association: Anti-inflammatory effects of conjugated linoleic acid on young athletic males., National Institute of Health, Medline Plus: Bone Marrow Diseases., Oxidative Medicine and Cellular Longevity: Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review., Restaurant Hospitality: Chefs make the most of versatile bone marrow.. The separation of these four components allows for multiple sources of data collection and offers insurance against otherwise compromised specimens. How do the different parts of a bone marrow workup relate to more in-depth analyses of morphology, markers, lineages, and overall diagnostic information? After the aspirate, the most expected informative component of a bone marrow workup is likely the core needle biopsy. When its lukewarm, check for any remaining fat and nerves and remove skin, starting at the thickest part of the meat towards the tip of the tongue. Bone marrow also contains significant portions of your reference daily intake (RDI) of the following nutrients and minerals: Fourteen grams of reindeer bone marrow contains: Although bone marrow is an excellent source of different vitamins and minerals, its also high in fat. Meanwhile, bring 1 of water to a boil in a 4-qt. In particular, collagen, glycine, glucosamine, and conjugated linoleic acid have been studied extensively for their potential effects on health. Lay slices of bone marrow lengthwise over scallops and truffles, and then broil until marrow is just melted, about 1 minute. Down in Juneau on 2nd Street sits a building where dough has risen almost every day for the better part of 100 years. Crack the black peppercorns. It is also rich in glucosamine, a compound that helps against osteoarthritis, relieves joint pain, and reduces inflammation in the joints. Q: Can the core biopsy determine the blast count? What Is Collagen, and What Is It Good For? hello, just thought i would make a few comments. Does it need to be pre roasted in the bone like when I spread it on toast, or can I put it into the sauce raw? Taste for seasoning, and then pour into four small shallow bowls. The four components of a routine bone marrow analysis. Your body holds just under 6 lbs. In part, each component is analyzed and interpreted in correlation together for a final report. Megakaryocytes (yellow circles) can be seen at low power. parish bourbon, aged rum, chicory, bitters blend, vodka, raspberry brandy, lemon, lychee, pomegranate, blanco tequila, sotol, lime, fresno chile, grapefruit soda, scottish whiskey, lemon, ume plum, pistachio orgeat, walnut, gin, campari marmalade, lemon, sparkling wine, pulled mozzarella,r red wine poached pears, watercress, pecans, pear sauce, greens, seasonal vegetables, soft boiled egg, honey dijon vinaigrette, greens, cured cucumber, confit tomato, herb vinaigrette, mixed greens, cremini mushroom, truffle vinaigrette, red onion, capers, fine herbs jus, charred cabbage and asparagus slaw, lemon, sauteed kale, frankfurt green sauce, crispy white beans, wilted tuscan kale, charred onion, bone marrow vinaigrette, 44 farms ground chuck, swiss cheese, horseradish sauce, sauteed mushrooms, fried shoestring onions, toasted potato bun, dill spear, French fries, pineapple shrub, cinnamon, lime, grapefruit soda, cucumber, pistachio orgeat, lime, rosewater, tonic. Each individual experiences pain differently, so the severity could vary from person to person. Place Hematopathologists can assess morphology, histologic architecture, and immunologic and phenotype profiles (Figure 2) across all four components to create a comprehensive report for your patient. These stem cells make red bone marrow, which creates blood cells and platelets for your blood. Its most concentrated in the spine, hip, and thigh bones. $29.00 Riverence Steelhead Trout Served with butternut squash gnocchi, toasted almonds, sauteed green beans, hen of the wood mushrooms and lemon brown butter. The color of red bone marrow is the result of red blood cell production. Glucosamine is often taken to treat symptoms of bone, joint, and inflammatory conditions. There are dozens of ways to add bone marrow to your diet. It's delicious, and will intensify the beef flavor of the sauce. Whatever the cause, you have reason to request a hematopathology workup and investigative studies. document.getElementById("ak_js_1").setAttribute("value",(new Date()).getTime()); This site uses Akismet to reduce spam. Your patients cytopenias remain unexplained. You want clean bones that are pale pink in color and come from animals that lived organically and range-free. if not you are making something else. So if you make a sauce using an excellent red Bordeaux wine and some demi-glace, you have a Bordelaise. Red bone marrow makes up all of your bone marrow until about age seven. Escoffier didn't come up with the brown mother sauce or the daughter bordelaise sauce, but he codified classic French cooking. This is a detailed article about bone broth and its health benefits. check books like escoffiers sauce bible or the professional chef for classical sauces. After the procedure, you may feel side effects, which include aches and pain at the site of the incision. If you buy through links on this page, we may earn a small commission Heres our process. Featured in: A Little Bit of Work and a Lot of Satisfaction, 773 calories; 73 grams fat; 1 gram saturated fat; 0 grams trans fat; 4 grams monounsaturated fat; 1 gram polyunsaturated fat; 20 grams carbohydrates; 3 grams dietary fiber; 4 grams sugars; 5 grams protein; 357 milligrams sodium. 37 Otherwise, you can ask them for shank bones, neck bones, knucklebones, or oxtail. Last reviewed by a Cleveland Clinic medical professional on 04/21/2022. Bone marrow can be scooped out after cooking. The prepared core biopsy slides can be used for immunohistochemical (IHC) investigations (phenotyping the cells using IHC stains), and an initial standard hematoxylin and eosin stain is done to assess baseline histology. The bone marrow aspirate is arguably the most straightforward aspect of the bone marrow workup. To prepare bone marrow, place marrow bones in a 450 (232) oven and roast for about 15 minutes. 25. mushroom cavatelli pasta mushroom ragu, greens, spicy peanuts sauteed kale, frankfurt green sauce, crispy white beans. however this is a classical sauce. Heat it up on a frying pan and let it Figure 5. Heres What You Should Be Grilling This Labo Taco Tuesday Problems: So Many Tacos, So Little Ti Cap Off Your Week With The Latest Mushroom News. A: No. WebWish-Bone vinaigrettes are the perfect addition to your salad or marinade. A complete bone marrow biopsy examination usually involves the review of these four specimens noted here in a slide tray: A) marrow aspirate smear, B) marrow core biopsy, C) clot section, and D) touch imprint preparation. Glycine and conjugated linoleic acid are both abundant in bone marrow, and theyve been shown to have strong anti-inflammatory properties. Two-dimensional fixed tissue specimens from the biopsy and clot are easily stained with immunohistochemical methods while three-dimensional, liquid cellular content can be assessed with flow cytometry. Although short-term inflammation is a crucial part of your bodys defense system, chronic inflammation is thought to contribute to conditions like heart disease, diabetes, and cancer (13). You can keep your bone marrow healthy by: Bone marrow is the soft center of the bones in your body. It is called fillet mignon when cut into individual steaks or medallions.). According to a 2-week study in 23 men, taking 5.6 grams of CLA per day effectively decreased levels of specific proteins involved in inflammation, including tumor necrosis factor alpha and C-reactive protein (17). These formalin specimens are embedded in paraffin blocks and sectioned by histotechnologists to provide a two-dimensional cross-section of the clotted tissue. (Stop before marrow begins to drizzle out.). A great way to use bone marrow is in a sauce, especially for meat dishes. Hypocellular or paucispicular smears preclude these assessments, which are not easily (or accurately) performed on the core biopsy (Table). Reprinted with permission fromState Bird Provisions: A Cookbook. However, what they all have in common is a Bordeaux-style red wine, and I guess if you truly want to call it Bordelaise, it should be made with a French Bordeaux wine which is typically a combination of Cabernet Sauvignon, Cabernet Franc & Merlot grapes. It should not be considered a substitute for a professional nutritionists advice. 40 minutes, plus at least 15 minutes draining, Alex Witchel, Isa Chandra Moskowitz, Terry Hope Romero. Since bone marrow is the foundation for the creation of blood cells, blood-related conditions often are the result of abnormally functioning bone marrow. Its often served with toast and marmalade. Lightly rub the exposed marrow in each bone with the garlic, then evenly season with the 1 Tbsp kosher salt and the black pepper and sprinkle with the thyme leaves. Benefits, Dosage, and Side Effects, 9 Health Benefits of Vitamin B12, Based on Science. Aspirate slides are also used for cytochemical and iron stains. All Rights Reserved. One family finished the sauce with butter and another with cream. In a medium-sized pot, prepare a broth with the onion, bay leaves, carrot, black peppercorn, oregano, cloves of garlic and leeks. That said, this specimen (if involved by a disease process) can be sent for genetic testing such as polymerase chain reaction and does not present the issue of being postdecalcification (which may hinder some genetic tests). Q: Can your pathologist tell you what the core biopsy shows on the same day as the procedure? Lemony Moroccan Lamb Stew with Garlic and Saffron, Cantonese White Cut Chicken with Ginger-Scallion Sauce, One-Pot Manchego Mac and Cheese with Pimentn Bread Crumbs, Roasted Parsnips and Onions with Sumac and Feta, 2 tbsp. Advertising on our site helps support our mission. November 1, 2015 by G. Stephen Jones 13 Comments. Often, cell mutations harm healthy bone marrow cells, and a bone marrow transplant would be a treatment option for people diagnosed with blood cancers like leukemia. These specimens are differentially used to study morphology, assess lineage, perform cell counts and differentials, triage and send for appropriate immunohistochemical stains, perform flow cytometry, and send ancillary cytogenetic and molecular genetic studies. Finally, add the fresh thyme & cracked peppercorns. We do not endorse non-Cleveland Clinic products or services. Remove fat and nerves. Registration on or use of this site constitutes acceptance of our Terms of Service. If youre going to add bone marrow to your diet, make sure to do so in moderation to avoid weight gain. How thick or rich you want your liquid to be will dictate how much marrow you put in. You can use bone marrow like you would work with any other type of oil. Table: Comparative advantages and drawbacks of the marrow aspirate versus the core biopsy. Spongy bone makes up the ends of your bones. Have you compared a homemade demi-glace with a quality purchased one side by side? Bone marrow is the soft, fatty tissue inside of the bones in your body. Roast for about 15 minutes. Make sure youre sourcing it from a quality butcher. It also contains protein, vitamin B12, riboflavin, collagen, and conjugated linoleic acid. In one 6-month study in 147 athletes, supplementing with 10 grams of collagen per day significantly decreased activity-related joint pain (12). All rights reserved. View an interactive bone marrow core biopsy online. Determination of cellular phenotype (what the cell expresses on its surface, or in its cytoplasm) on an aspirate is carried out by flow cytometry. To prepare bone marrow, place marrow bones in a 450 (232) oven and roast for about 15 minutes. To learn more about me Read More. Make the panna cotta Stir the gelatin into the cold buttermilk to bloom and set aside. Remove the pan from the heat source, add the red wine, return the pan to the heat and reduce for 2 to 3 minutes. Bone marrow is the soft, fatty tissue inside of bone cavities. Bone marrow produces red blood cells that carry oxygen, white blood cells that prevent infection and Components of your blood including red and white blood cells and platelets form inside of your bone marrow. This recipe first appeared in our March 2012 issue, with Mei Chin's article Bone Gatherer. Place in the refrigerator again for a few hours before serving so that the meat absorbs some of the vinaigrette and acquires even more flavor. Bordelaise sauce is a classic French sauce made from brown sauce infused with shallots, bone marrow, herbs, and wine. Q: Can flow cytometry be performed on the core biopsy? Bone marrow can be scooped out after cooking. Yellow bone marrow gradually replaces red bone marrow as you age. When ready to serve, sprinkle with the chopped parsley. Recently, it has become a main course item at gourmet restaurants around the world. Ergo, Bordelaise, in its most general form, refers to a wide range of dishes that incorporate wine, most notably Bordeaux wine. Required fields are marked *. Season with salt. After patient preparation, sedation, and the procedure itself, a bone marrow investigation provides four specimen types for pathologist review (Figure 1): the bone marrow core biopsy, the bone marrow touch imprint, the bone marrow aspirate smear, and the bone marrow clot particle. Well go over the specific functions of both red and yellow bone marrow. Season with teaspoon kosher salt and cook, stirring occasionally, until lightly golden, about 5 minutes. What Is the Difference Between Tomato Sauce and Tomato Paste, This Is How to Make Spicy Ragu Sauce Over Pasta, This Is How I Make Indian-Style Sauce Base, How to Make Fettuccini With Store-Bought Tomato Sauce. Though no studies directly evaluate the effects of consuming bone marrow, plenty of research on the health benefits of its components is available. Saut the shallots for a couple of minutes until they become translucent but be careful not to let them burn. Liquid, powder, and capsule (pill) products make it easy to add bone marrow into your cuisine. Picture of four bone marrow specimens in a slide tray. Save the leaves and discard the stems. Bone marrow also contains adiponectin, a type of protein hormone that has been shown to play a central role in regulating inflammation and immune function (18, 19). Add half the mushrooms to the skillet, spreading them in a single layer. Here are the top 9 health benefits and uses of glycine. Hematoxylin-eosinstained sections of the clot particle. Yes, they do, but their versions are not too similar. Since it is a two-dimensional specimen and reveals cells in cut section, it is not ideal for assessment of dysplasia (a marrow aspirate is preferred), but it is extremely useful in identifying possible reasons for a dry tap (a term for when liquid marrow cannot be aspirated during the bone marrow procedure), since the architecture can show fibrosis, sheets of cohesive plasma cells, or metastatic tumor which could result in a dry tap. Figure 4. Collagen is the most abundant protein in your body. Be sure to stir every so often so the sauce does not burn. Cleveland Clinic is a non-profit academic medical center. 2021 L Street NW, Suite 900,Washington, DC 20036, Phone 202-776-0544Toll Free 866-828-1231Fax 202-776-0545, Copyright 2023 by American Society of Hematology, Support Opportunities|Privacy Policy|Terms of Service|Contact Us, Helping hematologists conquer blood diseases worldwide, Demystifying the Bone Marrow Biopsy: A Hematopathology Primer, https://www.hematology.org/education/trainees/fellows/trainee-news/2021/demystifying-the-bone-marrow-biopsy-a-hematopathology-primer, Relative quantity of different cell types, Provides material for flow and molecular studies. Heat it up on a frying pan and let it melt. Wondering if you sacrifice a fair amount of taste by skipping the long process of creating it from scratch. Quick tip: A cellular aspirate smear is crucial to an adequate differential count and assessment of morphologic dysplasia. Without individual cells to analyze through flow cytometric methods, the clot section is limited to only tissue-type immunostaining. This hormone helps break down fats. Yellow bone marrow consists mostly of fat and stem cells that produce bone and cartilage in your body. While their individual turnaround times vary, these specimens are usually reported together to make sure all aspects are accounted for, which can take approximately three days on average. Remove the tongue from the water. Meanwhile, combine parsley, shallots and capers in small bowl. I'm a work-at-home dad who enjoys cooking, learning everything I can about the culinary world and sharing it with you. Its stem cells produce red and white blood cells. Before the specimen is transferred to a container with anticoagulant, some of the already clotted specimen may be submitted for permanent histology in formalin. WebThe perfect bite! Q: Can your pathologist give you a preliminary assessment of the aspirate smear or flow cytometry analysis on the same day as a procedure if it was performed early in the morning? It can maintain insulin sensitivity, and it has been linked to lower risk of diabetes, cardiovascular (heart) disease, and other obesity-associated cancers. I have seen it in many specialty food stores and once in a while in my local supermarket. Note granulocytic precursors (arrows) and erythroid cells (arrow heads). Note: Please review ASHs disclaimerregarding the use of the information contained in these articles. Pour in the bone marrow vinaigrette and toss to combine. Add the vinegar, mustard, Worcestershire sauce, and some salt and pepper. I'm sure they would be happy to. This provides an added texture and surprise goodie, but also proves that you used bone marrow. 2023 ,https://www.hematology.org/education/trainees/fellows/trainee-news/2021/demystifying-the-bone-marrow-biopsy-a-hematopathology-primer. While being the tenderest cut of meat, tenderloin is not the most flavorful. They have a great shelf life and I have them when I need them without the hours of work of preparing it from scratch. Brush the bread slices on both sides with olive oil and cook, flipping once, until toasted and brown in spots, about 5 minutes. His family operated A Spirit Most Adventurous When hot, add the butter, melt, and then the shallots. Bone marrow contains a good amount of calories and fat, as well as small amounts of nutrients like protein and vitamin B12. Return the first batch to the pan, remove the pan from the heat, cover, and set aside. Treating medical conditions where bone marrow abnormalities are a side effect. Bone core biopsy. A bone marrow transplant is a medical procedure performed to replace bone marrow that has been damaged or destroyed by disease or chemotherapy. Unlike complete blood counts (CBCs), which produce fast results, a bone marrow analysis requires a more in-depth analysis and, as a more invasive procedure, necessitates built-in redundancies to ensure the highest-quality results. 2005 - 2023 WebMD LLC. The bone marrow of animals like cows, lambs, caribou, and moose is commonly consumed in many types of cuisine. This is the closest you'll get to crediting a modern source. Soak in the fridge for 1 day more. Heat a saucepan over medium heat. What happens after you place the orders, though? saucepan with a steamer basket insert; add scallops and cook until cooked through, about 5 minutes. I remember my curiosity one particular day, after cleaning my plate and licking my fingers (and of course, getting a talking-to for my table manners), about the name of the tender, rica meat that she had prepared for me. One 8-week study in 69 women found that supplementing with 2.55 grams of collagen helped improve skin elasticity and hydration (20). Bone marrow is high in calories and fat. See our privacy policy. While the meat cooks in the broth, you should pinch it various times with a fork to check that it's tender enough. The menu offers classic French dishes built on refined techniques, but with unexpected ingredients and flair. Each of these four specimens have their strengths and limitations; therefore, they should be assessed separately. Maybe a routine peripheral smear caught some circulating blasts. I was trained to leave nice slices of marrow in the sauce. Wright-Giemsa staining of the marrow aspirate smear. More recently, it has become a delicacy in gourmet restaurants and trendy eateries alike. What is the hematopathologist looking for when assembling all the parts to report back in consultation with you? Bring distilled vinegar and 10 cups water to a boil in a 6-qt. Beau Schooler thinks so. Then, drain the diced marrow and reserve. Hematoxylin-eosinstained section of the bone core biopsy (100). (The actual cut of meat in its whole form is called the tenderloin. They are then stained and processed much like the original core biopsy. For the vinaigrette The specimen is fixed in paraffin and cut for slide preparation. Why do some investigations yield more, or less, information than others? WebVinaigrette. Filet Mignon Medallions* grilled filet / baby carrots / roasted fingerling potatoes / harissa. Bone marrow is widely available and can be extracted from roasted marrow bones. Repeat with the remaining grapeseed oil, mushrooms, and teaspoon kosher salt. You can use bones from nearly any animal, but beef bone marrow is a great choice for beginners due to the size of the bones and widespread availability. Cover and keep warm for up to 30 minutes. Does Bone Broth Protein Have Health Benefits? Preheat oven to 350. Bone marrow contains high levels of fat and calories, but it also has nutrients like vitamin B12. A: Ideally, no. Season with teaspoon of the kosher salt and the black pepper and continue to cook, stirring occasionally, until the shallot is translucent but not colored, about 3 minutes. Bring to a simmer then reduce heat to medium low. Since the marrow is abundantly deep red and more viscous than blood, the red cell and platelet components will eventually form clots if no anticoagulant is present. Collagen is a type of protein found throughout your body that plays an integral role in skin health. Though more research is needed, bone marrow is also thought to provide several other key compounds, including glycine, glucosamine, and chondroitin (7, 8, 9). "American Society of Hematology. Some of the most popular sources of bone marrow include: If youre planning on using your bone marrow as a base for bone broth or soups, you can use the whole bone in your recipe rather than extracting the marrow separately. Treatments for bone marrow conditions vary based on the severity and progress of the diagnosis. Place in the fridge to set overnight. Healthline Media does not provide medical advice, diagnosis, or treatment. Continue reducing the liquids until most of the wine is cooked off. WebD I N N E R. olympic oyster co. ridgeback*, tomatillo granita 5 ea bread & butter, sea wolf sourdough, sunchoke and black pepper butter 8 beef tartare*, bone marrow vinaigrette, caper, mustard, parsley, shallot 18 dungeness crab beignet, fresh black truffle, dill vadouvan aioli, frise 19 radicchio salad, cranberry, hazelnut, smoked blue cheese, duck fat potato This sauce is good on most cuts of grilled meats, including venison but is especially great on beef tenderloin or juicy sirloin steak. As such, the redundancies in place discussed here and the compound output of the four major components have synergistic effects on diagnostic evaluation. Here are 9 impressive health benefits of vitamin B12, based on. Touch preps can be imprinted, rolled, or crushed between glass to provide similar information. As bone marrow has gained popularity in top kitchens around the world, scientists and doctors have begun to take a closer look at the following health benefits it presents: One study showed that the fat tissue in bone marrow contains a hormone called adiponectin. Drain and let cool. Not sure where you live but ask a local butcher to get you some. Preparation Since this is a liquid sample, it does not need to undergo decalcification, can be smeared onto a slide and stained relatively quickly, used for flow cytometry (which needs unfixed, liquid cells), and sent fresh for molecular analysis. We are a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for us to earn fees by linking to Amazon.com and affiliated sites. While there are advantages and disadvantages to each component regarding turnaround time, comprehensiveness, and diagnostic utility (Table), their synergism provides ample information for your consultant hematopathologists. Arrange the marrow bones on a large platter, spoon on the mushrooms, and spoon about 2tablespoons of the sauce over each bone. Using a slotted spoon, transfer celery root to a food processor, and pure with 14 cup cooking liquid; transfer to a bowl, season with salt and pepper, and set aside. The traditional way to use bone marrow is in a broth or soup. There are two types of bone marrow in your body, which are characterized by their color. Sign up for the best of Food Republic, delivered to your inbox Tuesday and Thursday. Vitamin B12 is an essential nutrient that plays a vital role in keeping you healthy. Arrange the bones, cut side up, on
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